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KMID : 0882420110810030412
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Korean Journal of Medicine
2011 Volume.81 No. 3 p.412 ~ p.415
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A Case of Rheumatoid Arthritis Associated with Klinefelter’s Syndrome
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Seo Mi-Ryoung
Cho Hyun-Jung
Choi Hyo-Jin
Baek Han-Joo
Ahn Jeong-Yeal
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Abstract
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Klinefelter’s syndrome is a disorder of sexual differentiation in males, characterized by the presence of two or more X-chromosomes, hypogonadism, and lack of secondary sexual characteristics. The association between Klinefelter’s syndrome and systemic lupus erythematous has been described, while cases of rheumatoid arthritis associated with Klinefelter’s syndrome are rare. We report the first Korean case: a 29-year-old man with Klinefelter’s syndrome who developed rheumatoid arthritis. The sex hormone imbalance might have influenced the onset and course of his disease.
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KEYWORD
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Klinefelter’s syndrome, Rheumatoid arthritis, Sex hormones
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